The following studies are approved spin off studies in the CHECK study and are ongoing. The CHECK foundation welcomes new ideas for spin off studies. You can send in a permission request via EASY (DANS).  The CHECK data are stored in datasets in EASY, which is an online archiving system of Data Archiving and Networked Service (DANS).

Objective of the spin off study
To replicate the developed risk assessment tool in the CHECK study F.S. Hosnijeh
To compare the radiographs and MRI for the prediction of incident knee OA and knee pain J. Runhaar
To analyze the lntermittent and Constant OsteoArthritis Pain scale and its relationship with patient characteristics, quality of life, signs and symptoms in patients with hip and/or knee osteoarthritis. D. Schiphof
To develop and apply a 2D statistical shape model of the patellofemoral joint in order to investigate the influence of the joint geometry on patellofemoral pain and OA. M. van Middelkoop
What is the course of (physical) functioning, pain and quality of life in OA patients after OA diagnosis before surgical intervention M. Gademan
To identify osteoarthritis of the lumbar spine and lumbar vertebral fractures in patients with OA of hip or knee N. Kuchuk
Do genetic loci for mJSW, which were identified by GWAS meta-analysis of 5 cohorts, replicate in the CHECK study? J. van Meurs
To create a genome wide genetic (GWAS) database in CHECK J.van Meurs
To study the course of physical functioning (proprioception, inflammation, muscle weakness) of 6 year follow-up M. v.d. Esch
To determine the prevalence, incidence and determinants of arterial calcifications in the iliac and femoral arteries in CHECK and their association with OA and phenotype P.A. de Jong
To analyze the influence of the mitochondrial DNA haplogroup on radiographic OA progression F. Blanco Garcia
To identify the incidence and phenotype of patellofemoral OA N. Lankhorst
To identify an association of a non-synonymous SNP in the FAM173b gene with OA pain N. Eykelkamp
To understand how unfavourable metabolic profiles affects OA disease course I. Meulenbelt
To validate the Dutch-Flemish PROMIS item bank physical functioning in participants with early hip and/ or knee OA L. Roorda
Exploration of longitudinal patterns of fatigue experience in patients with OA C. Bode
To replicate the observed signals in CHECK by Squenom mass spectrometry of SNPs and analyse the data with sCOMP en sCTX2 levels in CHECK I. Meulenbelt
To determine the course and determinants of health care use in participants with early OA A. den Broeder
To analyse the relation between lumbar disc degeneration and self-reported low back complaints P. Luijsterburg
To describe the relation between Ox-LDL, macrophages and cartilage destruction during osteoarthritis P. van Lent
To determine the predictive value of S100A8/S100A9 alarmines for cartilage damage in serum of OA patients P. van Lent
To determine the clinical status of OA from x-ray analyses using active shape or appearance models. To predict OA disease progression from x-ray analyses using active shape or appearance models. H. Weinans
To analyse immuno and genexpressionpaterns in synovium and cartilage biopsies in early OA W.van den Berg
To assess the quality and utility of Functional Capacity Evaluation system in participants with early OA. A. Bieleman
To determine and analyse course of physical functioning in early OA M. Steultjens
To identify, explain and predict early processes with MRI in OA G. Kloppenburg
To determine the influence of foot- and ankel problems in the course of knee and hip OA K.Gorter
To analyse the association between adipokines and onset and progression of radiological damage and clinical status of CHECK participants F. Lafeber
To describe the clinimetric properties of the questionnaire ‘loopvaardigheid’ in participants with hip and knee OA L. Roorda
To identify genetic determinants for the onset of OA I. Meulenbelt
To increase reproducibility of WOMAC L. Roorda